E-mail: [email protected]om
E-mail: [email protected]om
ANDROGRAPHIS PANICULATA EXTRACT
Andrographis Paniculata Extract
Green Chirayta, Chuan Xin Lian, Kalmegh,King of bitters
8%,10% HPLC Andrographolide
Anti-inflammatory, immunomodulator, anticarcinogen,
Food additive, dietary supplement, medicine
What is Andrographis Paniculata?
Andrographis paniculata (Burm. f.) Wall. ex Nees (AP) is an important medicinal plant and
widely used around the world. It belongs to the family Acanthaceae. AP is used as a traditional
herbal medicine in Bangladesh, China, Hong Kong, India, Pakistan, Philippines, Malaysia,
Indonesia, and Thailandand is ethnobotanically used for the treatment of snake bite, bug bite,
diabetes, dysentery, fever, and malaria. In the Unani and Ayurvedic medicines, AP is one of the
mostly used medicinal plants.
In recent times, commercial preparations of this plant extracts are also used in certain countries.
However, the preparations yet need to be standardized for their better efficacy. The aerial part of
AP is most commonly used; its extracts contain diterpenoids, diterpene glycosides, lactones,
flavonoids, and flavonoid glycosides. Whole plant leaves and roots are also used as a folklore
remedy for different diseases in Asia and Europe. AP has been reported to have a broad range
of pharmacological effects including anticancer, antidiarrheal, antihepatitis, anti-HIV,
antihyperglycemic, anti-inflammatory , antimicrobial, antimalarial , antioxidant,
cardiovascular, cytotoxic , hepatoprotective, immunostimulatory , and sexual dysfunctions .
Benefits of Andrographis Paniculata Extract:
The anti-inflammatory effect occurs because the dehydroandro-grapholides stimulate the
production of ACTG in the hypophysis. The ACTG increases the synthesis and release of
corticosteroids, which have an anti-inflammatory effect.
Dehydroandro-grapholides have a direct inhibitor effect over NF-kapa beta-, which is an important
transcriptional factor related to the inflammatory response.
Andrographis paniculata is a powerful stimulant for the immunologial system, through both the
antigen specific and non specific way.
It optimizes the expression of the genes that codify the cytokines’ receptors, and the synthesis of
the histocompatibility molecules, type I and II; in this way, it improves the interaction between the
As it has been noted, malign cells appear when some cells do not respond to the signals that intend
to limit their growth. When cells mature properly, they define their specialization in order to
perform their respective functions. The carcinogenic cells are those that do not mature, and are
similar to the embryonal cells. The more immature they are, the more aggressive the tumor will be.
Scientist used Andrographis paniculata in a test done with mice. They discovered that the terpenes
from the plant caused the differentiation in Leukemia cells, making them to be more mature, and
therefore, less aggressive. The extract of Andrographis paniculata, as well as causing the
differentiation in cancerous cells, is also cytotoxic to those cells.
Andrographis paniculata is a powerful antiretroviral. All the viruses, including HIV, cannot
reproduce without using the replication machinery of the cells. The HIV virus sticks to the
cell, using CD4, CCR5 and CXCR4 molecules on its surface.
The viruses tend to concentrate in the brain tissues and in the immunocompetent cells, which
have those molecules, mainly CD4. When entering the cell, the viruses use a key enzyme to
multiply themselves and this is called Reverse Transcriptase.
The inhibitors of this enzyme are considered the most important agents used against AIDS;
however, these drugs are very toxic. The alkaloids of Andrographis paniculata increase the
action of the inhibitors over the Reverse Transcriptase, so that the dosage of the inhibitor drug
can be reduced. Andrographis paniculata inhibits the cyclon-dependant kinases’ phosphorilation
which is induced by the viruses so that the cellular cycle of the infected CD4 cells stops, as well
as the viruse’s dissemination.The alkaloids of Andrographis paniculata also reduce the
multiplication of the Hepatitis B, Herpes and Influenza viruses.
5. Cardioprotective and antithrombotic
Andrographolides reduce the procoagulant potential and improve the rheological properties of the