Ivy Leaf Extract alleviates bronchitis and helps patients with asthma. Bronchitis and asthma are
different diseases, but they have one feature in common-in both conditions the mucous
membranes of the airways produce large amounts of phlegm or mucus and this hinders breathing.
If the bronchi are narrowed further still by inflammation the patient may even become short of
breath. Scientific investigations have shown that a special extract from ivy leaves can give definite
relief from such symptoms, without any risk of the adverse side effects which may be associated
with certain therapeutic agents of chemical origin. In a large scale clinical trial comprising 99
adults between 25 and 70 years of age with acute or chronic bronchitis the efficacy of ivy leaf
extract was compared under double-blind conditions with that of Ambroxol.
Hederacoside C 5%~50%
The traditional uses of ivy leaf extract are to relieve series diseases including bronchitis,
whooping cough, arthritis, rheumatism, and dysentery in the form of syrup, powder, tablet,
capsules, soft gels, etc.
Ivy leaf extract benefits against cough and bronchitis
Ivy leaf extract is an expectorant, and it treats cough and cold symptoms. It is used in the
obstruction of airways in children that suffer from bronchial asthma; it has a good response on
whooping cough, spastic bronchitis and chronic cold.
Extracts from ivy leaves have well-proven themselves in children and adult applications.
Clinical studies with ivy leaf extracts demonstrate a clear improvement of important lung function
parameters, as well as of patients’ well being.
The saponins in ivy extract (alpha-hederin and hederacoside c) are responsible for the spasmolytic
and expectorant action. According to recent study results, the mode of action of ivy leaf is based
on an indirect β2-adrenergic activity of α-hedrin. According to the theory, the substance inhibits
the endocytosis ofβ2-receptors in the lung. Consequently, β2-receptors are hold in the lipid rafts
of the cellular membrane and thus be continuously activated by adrenalin. The numerous response
reactions include the production of surfactants in the lung epithelia. Especially surfactant protein B
(SP-B) decreases the surface tension, whereby mucous viscosity is reduced and coughing up
facilitated. Also the typical spasmolytic property of ivy can be explained by this theory, because
the increasedβ2-adrenergic receptiveness also leads to an amplified relaxation of smooth bronchial
The saponin fraction and isolated saponins were demonstrated to exhibit antiviral, antibacterial,
antimycotic, anti-anthelmintic, anti-imflammatory and cytotoxic effects. Additionally antioxidative
properities were shown for the saponins alpha-Hederin and hederasaponin C